The latest project that I have been working on has been a full 64 bit implementation, but not only that, the MOSS servers are running server 2008. I have to say that the IIS7 interface has taken some time to get used to, but I really like. The console’s interface is much more robust and feature rich, but I just really like how much more intuitive it is. There is a bit of a learning curve, but once you get used to it, it makes life much much easier. In fact, it seems that Sharepoint actually runs faster on IIS7/Server 2008 than on IIS6/Server2003.
Check the links: http://blogs.msdn.com/sharepoint/archive/2008/01/25/case-study-amd-deployment-on-windows-server-2008-and-sharepoint-server-2007-is-faster-and-more-manageable.aspx
http://blogs.msdn.com/joelo/archive/2007/08/03/wss-3-0-on-windows-2008-is-hot.aspx
Not only these, but my customers see it, and they are impressed.
If you have a spare server available and it will run Server 2008, get the WSS v3 bit (with SP1, please) and go to town. The only thing that you need to do before you install WSS is to install the .NET 3.0 role, which will in turn install IIS7 (you will be prompted, and you must allow). When you run the installer, and you have done the minimum steps as described above, the actual install process will take care of the other particulars for you. Once the install is complete, run the config wizard and have fun!

Click Add Features…

Tick the .NET Framework 3.0 Features box and then you will be prompted to add the IIS Role.

Click the Add Required Role Services.

Read the text (if desired) about the IIS Role installation and click next.

The default boxes selected here are fine for the installation, Sharepoint will add what it needs. If you want to select more, that is fine. You can always add or subtract later. Be advised that this could adversely affect Sharepoint. Click next when ready.

Now is time to install. One thing before you click install…notice the hyperlink at the bottom? Print, email or save this information…how cool is that? Documentation made simple(er). Click install.

Now the waiting…

And we’re done! Reboot, double click the Sharepoint installer, and get to playing!